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Protein ArrayOne D GelConfocal
 
 

Guang-Wu Wang, M.D., Ph.D.
Senior Research Associate/Research Manager

e-mail: guangwuw@hotmail.com

Curriculum vitae (PDF)

 

Education:

Master of Science Pathology
Norman Bethune University of Medical Sciences, China

M.D. Medicine
Jinzhou Medical College, China

Ph.D. Cardiovascular Pathology
Norman Bethune University of Medical Sciences, China

Research interest:

  • Mechanisms to protect the ischemic myocardium.
  • Aldehyde exposure exacerbates myocardial ischemic injury.
  • Analysis of functional sub-proteomes in the ischemic myocardium.
  • Transgenic models of cardiac disease and protection. Role of PKC in myocardial ischemia.

My research interests focus on the signaling pathways that are responsible for apoptotic cell death in response to ischemia and other oxidative stresses. I use a myocardial infarction model in the mouse in vivo and isolated/cultured cardiomyocytes in vitro for these studies. Furthermore, I am involved in investigating the mechanisms for the protein-protein interactions within PKCe protein complexes using immunohistochemical-based laser confocal microscopic techniques.

     
   

Publications:


1. Wang GW, Song C, Vondriska, Klein J, Cao X, Zhang J, Kang Y, D’Souza, and Ping P. Molecular conformation dictates module formation: Example of PKCe and Src tyrosine kinase. Am J Physiol Heart Circ Physiol. 2002;282:H1166-71.

2. Baines CP, Zhang J, Wang GW, Zheng YT, Xiu JX, Cardwell EM, Bolli R, Ping P. PKCe and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCe-MAPK interactions and differential MAPK activation in PKCe-induced cardioprotection. Circ Res. 2002;90:390-397.

3. Cai L, Li W, Wang GW, Guo L, Jiang Y, Kang YJ. Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes. 2002;51:1938-48.

4. Wang GW, Klein JB, Kang YJ. Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes. J Pharmacol Exp Ther. 2001;298:461-468.

5. Wang GW, Zhou ZX, Klein JB, Kang YJ. Inhibition of hypoxia/reoxygenation-induced apoptosis in metallothionein-overexpressing cardiomyocytes. Am J Physiol. 2001;280: H2292-H2299.

6. Lambert JC, Wang GW, and Kang YJ. Zinc inhibition of caspase-3 activation does not protect hela cells from apoptotic cell death. Toxicol Appl Pharmacol. 2001;175:89-93.

7. Kang YJ, Zhou ZX, Wang GW, Buridi A, and Klein JB. Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases. J Biol Chem. 2000;275:13690-13698.

8. Kang YJ, Zhou ZX, Wu HY, Wang GW, Saari JT, and Klein JB. Metallothionein inhibits myocardial apoptosis in copper-deficient mice: Role of atrial natriuretic peptide. Lab Invest. 2000;80:745-757.

9. Wang GW, and Kang YJ. Inhibition of doxorubicin toxicity in cultured neonatal mouse cardiomyocytes with elevated metallothionein levels. J Pharmacol Exp Ther. 1999;288: 938-944.

10. Wang GW, Schuschke DA, and Kang YJ. Metallothionein overexpressing neonatal mouse cardiomyocytes are resistant to hydrogen peroxide toxicity. Am J Physiol. 1999;276:H167-175.

11. Wang GW, Hu XQ, and Wen FX. A comparative study on the response to St. Thomas cardioplegic solution in neonatal and adult isolated rabbit heart during ischemia and reperfusion. Chi Circ J. 1997;12:149-151.

12. Wang GW, Zhao YZ, and Wang F. Protection of selenium on cumene hydroperoxide-induced ultrastructure injuries in cultured cardiomyocytes. Studies of Trace Elements and Health. 1996;13:8-9.

13. Wang GW, Wang F, Zhao YZ, Wang LZ, Zhou XB, Sun B, Zhang PY, and Xi SG. Effect of cumene hydroperoxide on DNA in cultured neonatal rat heart cells. J Norman Bethune Univ Med Sci. 1996;22:226-228.

14. Wang GW, Wang F, Zhao YZ, and Wang LZ. Protective effect of selenium on myocardial cells in culture to oxygen and glucose deprivation. Chi J Cont End Dis. 1996;11:137-139.

15. Wang GW, Zhao YZ, Wang F, and Li TY. Effect of cumene hydroperoxide induced changes on vitamin E content and membrane fluidity of cultured neonatal rat heart cells. Acta Nutrimenta Sinica. 1996;18:35-38.

16. Wang GW, Zhao YZ, Wang F, and Zhao ZT. Protective effect of vitamin E on lipid peroxidation in cultured heart cells of neonatal rats. Acta Nutrimenta Sinica. 1996;18:284-287.

17. Wang GW, Wang F, and Zhao YZ. Protection of selenium and vitamin E on cultured cardiac myocytes injured by lipid peroxidation. Chi J Endemiol. 1996;15:75-78.

18. Wang GW, Zhao YZ, Wang F, and Zhao Y. Effect of sodium nitrite on cell cycle in cultured neonatal rat myocardiocytes. Chi J Cell Biol. 1995;17:139-142.

19. Wang GW, Zhao YZ, Wang F, Zhao ZT, Xi SG, Liu W, Cui XM, and Li Y. Cytotoxicity of excessive selenium on cultured neonatal rat heart cells. Chi J Cont End Dis. 1995;10:133-135.

20. Wang GW, Zhao YZ, and Wang F. Effect of selenium on cumene hydroperoxide-induced DNA damage in cultured cardiomyocytes. Studies Trace Elements and Health. 1995;12:14-15.

21. Wang GW, Zhao YZ, Wang F, and Li C. Effect of sodium nitrite on cultured cardiac cells. Chi J Endemiol. 1995;14:345-347.

22. Wang GW, Wang F, Zhao YZ, and Sun B. Protective effect of Selenium on cardiac cellular injury by lipid peroxidation in culture. Studies of Trace Elements and Health. 1994;17-19.

23. Wang GW, Zhao YZ, Wang F, Li C, and Chen Y. Injurious effect of cumene hydroperoxide on cultured cardiac cells. J Norman Bethune Univ Med Sci. 1993;19:441-443.

24. Wang GW, Kang DR, Yang Q, and Wang F. Changes of NADH-methemoglobin reductase activity in erythrocytes of rats fed on grains from Keshan Disease area and the influence of selenium and vitamin E, B1. Chi J End Dis Cont. 1991;6:193-195.

 

 
 
 
       
     
 
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