David A. Liem, MD, PhD
Postdoctoral Fellow

e-mail: dliem@mednet.ucla.edu

Research interest:

My main interests in research are mechanisms to protect the heart against ischemia-reperfusion injury. As a medical doctor, my goal is to extrapolate findings in basic research into the clinical care area. Studying signal transduction pathways leading to protection against myocardial ischemia-reperfusion injury will help us in developing new therapeutic strategies to limit myocardial infarct size. Limitation of myocardial infarct size will mitigate development of remodeling and heart failure resulting in an improved cardiac function and a better quality of life in patients suffering from ischemic heart disease.

Publications:

1. Liem DA, Van de Doel MA, De Zeeuw S, Verdouw PD & Duncker DJ. Role of adenosine in ischemic preconditioning in rats depends critically on duration of the stimulus and involves both A1 and A3 receptors. Cardiovasc Res 2001; 51:701-708.

2. Duncker DJ, Haitsma DB, Liem DA, Heins N, Stubenitsky R, & Verdouw PD. Beneficial effects of the Ca2+ sensitizer EMD 57033 in Exercising pigs with infarction-induced chronic left ventricular dysfunction. Br J Pharmacol 2001; 134:553-562.

3. Liem DA, Verdouw PD, Ploeg H, Kazim S & Duncker DJ. Sites of action of adenosine in interorgan preconditioning of the heart. Am J Physiol 2002;283:H29-H37.

4. Liem DA, Verdouw PD & Duncker DJ. Transient limb ischemia induces remote ischemic preconditioning in vivo Circulation 2003;107(24):e218-9

5. McFalls EO, Liem DA, Schoonderwoerd K, Lamers J, Sluiter W & Duncker DJ. Mitochondrial function: the heart of myocardial preservation. J Lab Clin Med 2003; 142(3): 141-8.

6. Liem DA, Gho BC, Gho CC, Kazim S, Verdouw PD & Duncker DJ. Bis(maltolato)-oxovanadium attenuates myocardial reperfusion injury in a tyrosine-kinase dependent fashion J Pharmacol Exp Ther. 2004

7. Liem DA , Verdouw PD, te Lintel Hekkert M, Duncker DJ. Cardioprotection after tolerance to multiple episodes of ischemic preconditioning can be reinstated by both exogenous- and endogenous adenosine. Am J Physiol 2005;288:H1165-72

8. Liem DA , Wang GW, Vondriska TM, Honda HM, Qiao X, Korge P, Pantaleon DM, Wang Y, Weiss JN, Ping P. Nitric oxide induces late phase preconditioning against myocardial infarction via modulation of mitochondrial permeability transition. Am J Physiol 2005;288:H1290-5

9. Duncker DJ, Haitsma DB, Liem DA , Verdouw PD, Merkus D. Autonomic dysfunction in swine with a recent myocardial infarction is unmasked during exercise. Cardiovasc Res 2005;65:889-96

10. Berhane BT, Zong C, Liem DA , Huang A, Edmondson RD, Jones RC, Ping P, Vondriska TM.
Cardiovascular related proteins identified by the HUPO Plasma Proteome Project pilot phase. Proteomics 2005;5:3520-3530