Philip Doran, PhD
Postdoc Fellow

email: pdoran@mednet.ucla.edu

Research interest:

I have moved from Ireland where my primary research interests was the proteomic profiling of aged and dystrophin-deficient muscle fibers. I have joined the Ping lab to further characterize the composition of the 26S Proteasome / Mitochondria in cardiac cells by employing both expression and functional proteomic techniques.

Publications:

1. O’Connell, K, Doran, P, Gannon, L and Ohlendieck, K. Lectin-based proteomic profiling of aged skeletal muscle: Decreased pyruvate kinase isozyme M1 exhibits drastically increased levels of N-glycosylation. Eur.J. Cell Biol (2008) In Press
2. Doran, P, O’Connell, K, Gannon, J, Kavanagh, M and Ohlendieck, K. Opposite Pathobiochemical fate of pyruvate kinase and adenylate kinase in aged rat skeletal muscle as revealed by proteomic DIGE analysis. Proteomics. (2008) 2, 364-377.
3. Doran, P, Gannon, J, O’Connell, K and Ohlendieck, K. Aging skeletal muscle shows a drastic increase in the small heat shock proteins α-B crystallin/HspB5 and cvHsp/HspB7. (2007). Eur.J.Cell Biol 10, 629-640
4. O’Connell, K, Gannon, J, Doran, P, and Ohlendieck, K. Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle. Int. J Mol Med. (2007), 20, 145-53
5. Doran, P, Donoghue, P, O’Connell, K, Gannon, J, and Ohlendieck, K. Proteomic profiling of pathological and aged muscle fibres by peptide mass finger printing. Int. J Mol Med. (2007). 19: 547-564.
6. Donoghue, P, Doran, P, Padersen, K, Dunn, M.J, and Ohlendieck, K. Proteomic profiling of chronic low frequency stimulated muscle. Proteomics (2007) 18: 3417-3430.
7. Doran, P, Martin, G, Dowling, P, Jockusch, H and Ohlendieck, K. DIGE analysis of the mdx diaphragm proteome reveals a drastic increase in the heat shock protein cvHSP. Proteomics. (2006), 6, 4610-4621. (Front cover).
8. Doran, P, Dowling, P, Donoghue, P, Buffini, M and Ohlendieck, K. Reduced expression of regucalcin in young and aged mdx diaphragm indicates abnormal cytosolic calcium handling in dystrophin-deficient muscle. Biochem Biophys Acta, (2006), 1764, 773-785.
9. Donoghue, P, Doran, P, Dowling, P and Ohlendieck, K. Differential expression analysis of the fast skeletal muscle proteome following chronic low- frequency stimulation. Biochemt Biophys  Acta, (2005), 1752, 166-176.
10. Doran, P, Dowling, P, Lohan, J, Mc Donnell, K, Poetsch, S, and Ohlendieck, K. Subproteomics analysis of Ca2+ - binding proteins demonstrates decreased calsequestrin expression in dystrophic mouse skeletal muscle. Eur. J. Biochem (2004), 271, 3943-3953
11. Dowling, P, Doran, P, and Ohlendieck, K. Drastic reduction of Sarcalumenin in Dp427 (Dystrophin of 427 kDa)- deficient fibres indicates that abnormal calcium handling plays a key role in muscular dystrophy. Biochem J. (2004), 379, 479-488.