Aldrin Gomes , PhD
Assistant Research Physiologist

e-mail: avgomes@mednet.ucla.edu

Research interest:

My research interests focus on determining the importance of the ubiquitin-proteasome system in cardioprotective signaling. The ubiquitin-proteasome system is the primary mechanism of protein degradation in all cells. Functional proteomics is being utilized to investigate the proteasome complex in the normal, protected, and diseased heart.

Publications:

1. Gomes, A.V., Zong, C., Edmondson, R., Li, X., Stefani, E., Zhang, J., Jones, R.C., Thyparambil, S., Wang, G.W., Qiao, X., Bardag-Gorce, F., Ping, P. (2006) Mapping the Murine Cardiac 26S Proteasome Complexes. Circulation Research in press.

2. Zong, C., Gomes, A.V., Drews, O., Li, X., Young, G.W., Berhane, B., Qiao, X., French, S.W., Bardag-Gorce, F., Ping, P. (2006) Regulation of Murine Cardiac 20S Proteasomes: Role of Associating Partners. Circulation Research in press.

3. Ross E. M., Mateu, D., Gomes, A.V., Arana, A., Tran, T., Litosch, I. (2006) Structural Determinants for Phosphatidic Acid Regulation of Phospholipase C-ß1. J. Biol. Chem. in press.

4. Gomes, A.V., Zong, C., Ping, P. (2006) Protein Degradation by the 26S Proteasome System in the Normal and Stressed Myocardium. Antioxidants & Redox Signaling 9/10:1677-1691.

5. Gomes, A.V., Liang, J.S., Potter, J.D. (2005) Mutations in Human Cardiac Troponin I that is associated with Restrictive Cardiomyopathy affect basal ATPase Activity and Calcium Sensitivity of Force Development. J. Biol. Chem. 280:30909-15.

6. Gomes, A.V., Harada, K. and Potter, J.D. (2005) Effect of the N-terminal Familial Hypertrophic Cardiomyopathy causing Mutation, R21C, on the Physiological Function of Human Cardiac Troponin I. J. Molecular and Cellular Cardiology 39:754-765.

7. Venkatraman, G., Gomes, A.V., Kerrick, G.W., Potter, J.D. (2005) Characterization of Troponin T Dilated Cardiomyopathy Mutations in the Fetal Troponin. J. Biol. Chem. 280, 17584-92.

8. Everhart, D., Cartier, G.E., Malhotra, A. Gomes, A.V., McIntosh, J.M., and Luetje, C.W. (2004) Determinants of potency on alpha-conotoxin-MII, a peptide antagonist of neuronal nicotinic receptors. Biochemistry 43, 2732-2737.

9. Gomes, A.V., Venkatraman, G., Davis, J.P., Tikunova, S.B., Engel, P., Solaro, R.J., and Potter, J.D. (2004) Cardiac Troponin T Isoforms affect the Calcium Sensitivity of Force Development in the presence of Slow Skeletal Troponin I: Insights into the Role of Troponin T isoforms in the Fetal Heart. J. Biol. Chem. 279, 49579-87.

10. Gutierrez-Ford, C., Levay, C., Gomes, A.V., Perera, E.M., Benovic, J.L., Berkovitz, G.D. and Slepak, V.Z. (2003) Tescalcin, a Novel Calcium-binding Protein with a single EF-Hand: Metal-binding properties, localization in tissues and cells, and effect on calcinuerin. Biochemistry 42, 14553-14565.

11. Venkatraman, G., Harada K., Gomes, A.V., Kerrick, W. G., Potter, J.D. (2003) Different functional properties of two troponin T mutants that cause Dilated Cardiomyopathy. J. Biol. Chem. 278, 41670-41676.

12. Gomes, A.V., Guzman, G., Zhao, J., and Potter, J.D. (2002) Cardiac Troponin T Isoforms Affect the Ca2+ Sensitivity and Inhibition of Force Development. Insights into the Role of Troponin T Isoforms in the Heart. J. Biol. Chem. 277, 35341-35349.

13. Lang, R.,* Gomes, A.V.,* Zhao, J., Housmans, P.R., Miller, T., and Potter, J.D. (2002) Functional Analysis of a Troponin I (R145G) Mutation Associated with Familial Hypertrophic Cardiomyopathy. J. Biol. Chem. 277, 11670-11678.* contributed equally to paper.

14. Szczesna, D., Ghosh, D., Li, Q., Gomes A.V., Guzman, G., Arana, C., Zhao, J., Zhi, G., Stull, J.T., and Potter, J.D. (2001) Familial Hypertrophic Cardiomyopathy Mutations in the Regulatory Light Chains of Myosin affect their structure, Calcium binding, and phosphorylation. J. Biol. Chem. 276, 7086-7092.

15. Miller, T., Szczesna, D., Housmans P.R., Zhao, J., deFreitas, F., Gomes A.V., Culbreath, L., McCue, J., Wang, Y., Xu, Y., Kerrick, W.G., Potter, J.D. (2001) Abnormal Contractile Function in Transgenic Mice Expressing an FHC-Linked Troponin T (179N) Mutation. J. Biol. Chem. 276, 3743-3755.

16. Cuervo, A.M., Gomes, A.V., Barnes, J.A and Dice, J.F. (2000) Selective degradation of Annexins by Chaperone-Mediated Autophagy. J. Biol. Chem. 275, 33329-33335.