Qining Qin , MD PhD
Postdoc Fellow

e-mail: qqin@ucla.edu

Research interest:

Cardiac muscle death will follow after a coronary artery is obstructed in a heart attack. It was first found in 1986 that a brief period of coronary blood flow deprivation followed by reperfusion made the heart become resistant to a more prolonged cessation of coronary blood supply. This is so-called preconditioning. Understanding the mechanisms of cardiac preconditioning might help design some therapeutic approaches to tackle the problem of myocardial infarction. My research interests have been the studies aimed at mapping out the signal transduction pathways leading to cardioprotection in preconditioned hearts using the Langendorff model.

Publications:

1. Krieg T, Qin Q, Alexeyev MF, Cohen MV, Downey JM. Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS. Am J Physiol Heart Circ Physiol. 2004;287(6):H2606-11

2. Qin Q, Yang XM, Cui L, Critz SD, Cohen MV, Browner N, Lincoln TM, Downey JM. Exogenous Nitric Oxide Triggers Preconditioning by a cGMP- and mKATP-dependent Mechanism. Am J Physiol Heart Circ Physiol. 2004;287(2):H712-8

3. Krieg T, Cui L, Qin Q, Cohen MV, Downey JM. Mitochondrial ROS generation following acetylcholine-induced EGF receptor transactivation requires metalloproteinase cleavage of proHB-EGF. J Mol Cell Cardiol. 2004;36(3):435-43.

4. Oldenburg O, Qin Q, Krieg T, Yang XM, Philipp S, Critz SD, Cohen MV, Downey JM. Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection. Am J Physiol Heart Circ Physiol. 2004;286(1):H468-76.

5. Qin Q, Downey JM and Cohen MV. Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinas. Am J Physiol Heart Circ Physiol. 2003;284(2):H727-34.

6. Krieg T, Qin Q, McIntosh EC, Cohen MV, Downey JM. ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases. Am J Physiol Heart Circ Physiol. 2002;283(6):H2322-30.

7. Krenz M, Yang XM, Qin Q, Downey JM, Cohen MV. Dose-response relationships of the protective and antiprotective effects of acute ethanol exposure in isolated rabbit hearts. Heart Dis. 2002;4(5):276-81.

8. Yue Y, Qin Q, Cohen MV, Downey JM, Critz SD. The relative order of mKATP channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart. Cardiovasc Res. 2002;Aug.15;55(3):681-9.

9. Oldenburg O, Qin Q, Sharma AR, Cohen MV, Downey JM, Benoit JN. Acetylcholine leads to free radical production dependent on KATP channels, Gi proteins, phosphatidylinositol 3-kinase and tyrosine kinase. Cardiovasc Res. 2002;Aug.15;55(3):544-52.