| Project
Description: |
Project 3 will address the
underlying molecular signaling of ischemic injury and protection
from a perspective of novel protein kinase and phosphatase
regulations. Pathological remodeling, including mitochondrial
dysfunction can lead to altered energy metabolism and apoptotic cell
death as part of the deleterious consequences of myocardial
infarction. The intracellular signaling events that mediate
stress-induced pathological remodeling and myocyte apoptosis involve
intricate regulation by protein kinases and phosphatases. The
proposed studies will investigate the regulatory role of novel
protein kinases and phosphatases in mitochondria function in
response to ischemia/reperfusion, and uncover novel insights
concerning stress signaling in mitochondrial dysfunction during
ischemic injury. Ultimately, the study may lead to new therapeutic
approaches to attenuate cardiac injury following myocardial
infarction. |
